Chlorogenic acid, an ester of caffeic acid and quinic acid, is a major phenolic compound in coffee, but is also found widespread in plants and can be isolated from the leaves and fruit This compound, long known as an antioxidant, also slows the release of glucose into the bloodstream after a meal.
This acid is an important factor in plant metabolism. It is also an antioxidant and an inhibitor of the tumor promoting activity of phorbol esters; at concentrations as high as 100 µg/L, does not inhibit the 5-lipoxygenase activity of ionophore-stimulated human polymorphonuclear leukocytes.
Chlorogenic acid and caffeic acid are antioxidants in vitro and might therefore contribute to the prevention of Type 2 Diabetes Mellitus and cardiovascular disease .
Chlorogenic acid is an important factor in plant metabolism. It is also an antioxidant and an inhibitor of the tumor promoting activity of phorbol esters.Chlorogenic acid, at concentrations as high as 100 um, does not inhibit the 5-lipoxygenase activity of ionophore-stimulated human polymorphonuclear leukocytes.
Chlorogenic acid, an ester of caffeic acid and quinic acid, is a major phenolic compound in coffee; daily intake in coffee drinkers is 0.5–1 g. Chlorogenic acid and caffeic acid are antioxidants in vitro and might therefore contribute to the prevention of cardiovascular disease.
Chlorogenic acid has been proven in animal studies in vitro to inhibit the hydrolysis of the glucose-6-phosphate enzyme in an irreversible fashion. This mechanism allows chlorogenic acid to reduce hepatic glycogenolysis (transformation of glycogen into glucose) and to reduce the absorption of new glucose. In addition, in vivo studies on animal subjects have demonstrated that the administration of chlorogenic acid lessens the hyperglycemic peak resulting from the glycogenolysis brought about by the administering of glucagen, a hyperglycemiant hormone. The studies also confirmed a reduction in blood glucose levels and an increase in the intrahepatic concentrations of glucose-6-phosphate and of glycogen.
Chlorogenic acid can be used as anti-infectious active ingredient, it has wide anti-virus, anti-bacteria effects, and has relatively lower toxicity and side-effects. It has obvious anti-infectious effects, and does not like to lead Anti-microbial Resistance.
Due to its obvious anti-infectious effects, it not only can be used in pharmaceutical field but can be used widely in many other fields like food, feed additives, cosmetics also.
Chlorogenic Acid—Best ingredients for cosmetic products
Basic Information of Chlorogenic Acid
Molecular formula: C16H18O9
Molecular weight: 354.31
CAS No.: 327-97-9
Solubility: Good solubility in water
Appearance: Fine crystal powder
Specific Rotation [α]: -36° (c=1, H2O)
What is Chlorogenic acid:
Chlorogenic acid is a phenolic natural product isolated from the leaves and fruits of dicotyledonous plants, including the coffee bean, . Structurally, chlorogenic acid is the ester of caffeic acid with the 3-hydroxyl group of quinic acid.
Chlorogenic acid, an ester of caffeic acid and quinic acid, is a major phenolic compound in coffee, but is also found widespread in plants and can be isolated from the leaves and fruit . This compound, long known as an antioxidant, also slows the release of glucose into the bloodstream after a meal.
Information about Honeysuckle Flower
Honeysuckle Flower,Also known as- Lonicera spp, jin yin hua, lonicera.
The fragrant yellow flowers of the honeysuckle vine are used in herbal medicine around the world for cleansing, consuming, and digesting„and the flowers of Lonicera japonica, or Japanese honeysuckle, have the added property of stimulating circulation to remove inflammation.
In Traditional Chinese medicine, honeysuckle flowers are among the important herbs for clearing heat and relieving toxicity. This herb relieves "fire toxicity" manifesting itself as hot, painful sores or swellings of the eyes, throat, or breast. It expels "wind-heat" manifesting itself as sore throat or headache after explore to cold. And it treats "damp heat" manifesting itself as bladder infection. Modern laboratory research has confirmed that the flowers have an inhibitory effect on the bacteria that cause salmonella, staph, strep, pseudomonas, and tuberculosis infections.
Honeysuckle Flower is drink as a kind of tea for more than 2000 years in Japan and China.
Chlorogenic Acid, Inositol, luteolin, tannins.
The dried flowers, harvested just before the bud opens. Some products used to treat boils and abscesses include honeysuckle bark.
Teas and tinctures. Traditionally combined with mint for rashes or outbreaks on the skin following nervous tension, and with scutellaria to treat boils.
Honeysuckle flowers act as natural antihistamine, although they are more useful for treating rashes and inflammation than for treating coughing and sneezing. Some Japanese health food products include honeysuckle for treating bloating, nausea, and vomiting caused by hepatitis C.
Avoid when there is chronic diarrhea caused by cancer treatment, HIV, hepatitis C, or other chronic disease.
HPLC Chromatogram of 99% Chlorogenic Acid
Why Organic Herb Inc. Chlorogenic acid: