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Hops Flower Extract 0.4% Xanthohumol Humulus lupulus Extract

Hops Flower Extract 0.4% Xanthohumol Humulus lupulus Extract

  • Product No.: OHI-01000262
  • CAS No.： 6754-58-1
  • Active Ingredient: iso-alpha-acids ,alpha-acids
  • Specification: 0.4%
  • Test Method： HPLC

iso-alpha-acids ,alpha-acids

CAS No:6754-58-1
English Name:XANTHOHUMOL;XANTHOHUMOL, HUMULUS LU PULUS;2',4',4-TRIHYDROXY-6'-METHOXY-3'-PRENYLCHALCONE;Xanthohumol from hop (Humulus lupulus)
CB Number:CB5128899
molecular Formula: C21H22O5
molecular weight: 354.4
MOL File:6754-58-1.mol
 
Xanthohumol (XN) is a prenylated flavonoid found naturally in the flowering hop plant (Humulus lupulus) which is commonly used to make the alcoholic beverage known as beer. Xanthohumol is one of the major constituents of Humulus lupulus. Xanthohumol has been reported to have sedative property, Antiinvasive effect, estrogenic activity, cancer-related bioactivities, antioxidant activity, stomachic effect, antibacterial and antifungal effects in recent studies. However, the pharmacological functions of xanthohumol on platelets were not yet understood, we are interested in investigating the inhibitory effects of xanthohumol on cellular signal transduction during the process of platelet activation.

HPLC fingerprinting:

 

More Scientific Studies :

  1. Delmulle L, Bellahcene A, Dhooge W, Comhaire F, Roelens F, Huvaere K, Heyerick A, Castronovo V, De Keukeleire D.
    Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines.
    Phytomedicine. 2006 May 4; PMID: 16678392
  2. Colgate EC, Miranda CL, Stevens JF, Bray TM, Ho E.
    Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells.
    Cancer Lett. 2006 Mar 22; PMID: 16563612
  3. Albini A, Dell'Eva R, Vene R, Ferrari N, Buhler DR, Noonan DM, Fassina G.
    Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets.
    FASEB J. 2006 Mar; 20(3):527-9. PMID: 16403733
  4. Lust S, Vanhoecke B, Janssens A, Philippe J, Bracke M, Offner F.
    Xanthohumol kills B-chronic lymphocytic leukemia cells by an apoptotic mechanism.
    Mol Nutr Food Res. 2005 Sep;49(9):844-50. PMID: 16144030
  5. Gerhauser C, Frank N.
    Xanthohumol, a new all-rounder?
    Mol Nutr Food Res. 2005 Sep;49(9):821-3. PMID: 16144029
  6. Nozawa H.
    Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice.
    Biochem Biophys Res Commun. 2005 Oct 28;336(3):754-61. PMID: 16140264 
  7. Dietz BM, Kang YH, Liu G, Eggler AL, Yao P, Chadwick LR, Pauli GF, Farnsworth NR, Mesecar AD, van Breemen RB, Bolton JL.
    Xanthohumol isolated from Humulus lupulus inhibits menadione-induced DNA damage through induction of quinone reductase.
    Chem Res Toxicol. 2005 Aug;18(8):1296-305. PMID: 16097803
  8. Gerhauser C.
    Broad spectrum anti-infective potential of xanthohumol from hop (Humulus lupulus L.) in comparison with activities of other hop constituents and xanthohumol metabolites.
    Mol Nutr Food Res. 2005 Sep;49(9):827-31. PMID: 16092071
  9. Hussong R, Frank N, Knauft J, Ittrich C, Owen R, Becker H, Gerhauser C.
    A safety study of oral xanthohumol administration and its influence on fertility in Sprague Dawley rats.
    Mol Nutr Food Res. 2005 Sep;49(9):861-7. PMID: 16092070
  10. Hanske L, Hussong R, Frank N, Gerhauser C, Blaut M, Braune A.
    Xanthohumol does not affect the composition of rat intestinal microbiota.
    Mol Nutr Food Res. 2005 Sep;49(9):868-73. PMID: 16092067
  11. Pan L, Becker H, Gerhauser C.
    Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway.
    Mol Nutr Food Res. 2005 Sep;49(9):837-43. PMID: 15995977
  12. Vanhoecke B, Derycke L, Van Marck V, Depypere H, De Keukeleire D, Bracke M.
    Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer.
    Int J Cancer. 2005 Dec 20;117(6):889-95. PMID: 15986430
  13. Gerhauser C.
    Beer constituents as potential cancer chemopreventive agents.
    Eur J Cancer. 2005 Sep;41(13):1941-54. Review. PMID: 15953717
  14. Frolich S, Schubert C, Bienzle U, Jenett-Siems K.
    In vitro antiplasmodial activity of prenylated chalcone derivatives of hops (Humulus lupulus) and their interaction with haemin.
    J Antimicrob Chemother. 2005 Jun;55(6):883-7. PMID: 15824094
  15. Goto K, Asai T, Hara S, Namatame I, Tomoda H, Ikemoto M, Oku N.
    Enhanced antitumor activity of xanthohumol, a diacylglycerol acyltransferase inhibitor, under hypoxia.
    Cancer Lett. 2005 Mar 10;219(2):215-22. PMID: 15723722
  16. Wang Q, Ding ZH, Liu JK, Zheng YT.
    Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus.
    Antiviral Res. 2004 Dec;64(3):189-94. PMID: 15550272
  17. Stevens JF, Page JE.
    Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
    Phytochemistry. 2004 May;65(10):1317-30. PMID: 15231405 
  18. Casaschi A, Maiyoh GK, Rubio BK, Li RW, Adeli K, Theriault AG.
    The chalcone xanthohumol inhibits triglyceride and apolipoprotein B secretion in HepG2 cells.
    J Nutr. 2004 Jun;134(6):1340-6. PMID: 15173394
  19. Buckwold VE, Wilson RJ, Nalca A, Beer BB, Voss TG, Turpin JA, Buckheit RW 3rd, Wei J, Wenzel-Mathers M, Walton EM, Smith RJ, Pallansch M, Ward P, Wells J, Chuvala L, Sloane S, Paulman R, Russell J, Hartman T, Ptak R.
    Antiviral activity of hop constituents against a series of DNA and RNA viruses.
    Antiviral Res. 2004 Jan;61(1):57-62. PMID: 14670594
  20. Gerhauser C, Alt A, Heiss E, Gamal-Eldeen A, Klimo K, Knauft J, Neumann I, Scherf HR, Frank N, Bartsch H, Becker H.
    Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop.
    Mol Cancer Ther. 2002 Sep;1(11):959-69. PMID: 12481418
  21. Miranda CL, Stevens JF, Ivanov V, McCall M, Frei B, Deinzer ML, Buhler DR.
    Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro.
    J Agric Food Chem. 2000 Sep;48(9):3876-84. PMID: 10995285
  22. Miranda CL, Aponso GL, Stevens JF, Deinzer ML, Buhler DR.
    Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells.
    Cancer Lett. 2000 Feb 28;149(1-2):21-9. PMID: 10737704
  23. Miranda CL, Stevens JF, Helmrich A, Henderson MC, Rodriguez RJ, Yang YH, Deinzer ML, Barnes DW, Buhler DR.
    Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines.
    Food Chem Toxicol. 1999 Apr;37(4):271-85. PMID: 10418944
  24. Tabata N, Ito M, Tomoda H, Omura S.
    Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus.
    Phytochemistry. 1997 Oct;46(4):683-7. PMID: 9366096
  25. Tobe H, Muraki Y, Kitamura K, Komiyama O, Sato Y, Sugioka T, Maruyama HB, Matsuda E, Nagai M. 
    Bone resorption inhibitors from hop extract.
    Biosci Biotechnol Biochem. 1997 Jan;61(1):158-9. PMID: 9028043
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